Clinical Research Repository Disburser
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
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Repository: Prostate SPORE

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General

The SPORE repository has more than 50,000 specimen aliquots from more than 4,500 consented patients with prostate cancer treated at Northwestern Memorial Hospital and NorthShore University Health System. In addition to frozen tissue on nearly 3,500 patients, the repository has blood (serum, plasma, peripheral blood mononuclear cells, and blood spots) and urine samples. Sample accrual has been expanded to include not only patients undergoing surgery, but also non-surgical patients with advanced disease who are undergoing radiotherapy or chemotherapy, thus spanning the spectrum of disease. Corresponding formalin-fixed paraffin-embedded (FFPE) tissue is available on each prostatectomy case, and biopsies are available in most cases as well. More than 50 tissue microarrays have been generated and are available to interested investigators for research studies. Detailed clinical and pathologic data associated with each specimen is uploaded by data coordinators into the SPORE database sample management systems with appropriate protection of patient confidentiality.

  • IRB Process: IRB approval or exemption must be obtained prior to release of data or specimens. The request form will ask you input your IRB number or declare your IRB exemption.
  • Scientific Justification: The request form will ask you to attach a 'Methods/Justifications' document that should contain a scientific explanation jutifying the disburment of the clincial data and/or clinical speicmens.
  • Questions:
    • For all other questions about the specimen request process, please contact:
    • To discuss your specimen needs, please contact a SPORE Biospecimen director:
Specimen

Here is a breakdown of the specimen types avaible from the Prostate SPORE:

Sampe Type Count
Blood MNC 4,100
Blood Plasma 12,183
Blood Plasma Followup 120
Blood Serum 8,607
Buffy+RBC 645
DNA 2,627
Frozen Tissue 14,378
Prostatic Fluid 1299
Seminal Vesical Fluid 615
Separated T-Lymphocytes 248
Stained Tissue Slide 7,799
Tissue FPE Block 223
Trizol 32
Urine 2,347
Urine (spun) 1635
Whole Blood 644
Data

The  broad categories of the clinical data points collected within the Prostate SPORE are the following:

  • Demographics
  • Family History
  • Comorbidities
  • Diagnosis
  • Treatment
  • Followup
  • Survival

A complete listing of all the clinical data points available are detailed in the data dictionary document above.

Here is a high-level breakdown of the most commonly requested clinical data points available from the Prostate SPORE.

Pathological Stage by Age at Diagnosis

path_stage 20-29 30-39 40-49 50-59 60-69 70-79 80-89 90-99 100-109
NULL 0 0 3 23 39 17 6 1 0
N1 0 0 1 17 18 8 0 0 0
T0 0 0 0 5 2 2 0 0 0
T2a 0 2 45 231 318 64 2 0 0
T2b 0 1 15 46 38 13 0 0 0
T2c 0 2 178 979 1169 244 2 0 1
T3a 0 1 23 266 388 136 3 0 0
T3b 0 1 13 72 105 44 0 0 0
T3c 0 0 7 30 49 12 0 0 0
T4 0 0 0 2 5 0 0 0 0

Pathological Stage by Race 

Pathological Stage American Indian or Alaska Native Asian Black More than one race Native Hawaiian or Other Pacific Islander Unknown White
NULL 0 0 9 0 0 5 75
N1 0 1 2 1 0 1 39
T0 0 0 0 0 0 1 8
T2a 0 10 20 0 0 20 612
T2b 0 1 6 0 0 27 79
T2c 2 39 179 1 1 76 2271
T3a 0 18 50 3 0 30 714
T3b 1 3 22 0 0 8 201
T3c 0 1 4 0 0 3 90
T4 0 0 1 0 0 0 6

Gleason Score by Age at Diagnosis 

Gleason Score 20-29 30-39 40-49 50-59 60-69 70-79 80-89 90-99 100-109
2+2 0 0 0 4 2 0 0 0 0
2+3 0 0 1 2 7 0 0 0 0
2+4 0 0 0 0 1 0 0 0 0
3+2 0 0 2 6 9 3 0 0 0
3+3 0 6 149 713 712 109 2 0 0
3+4 0 0 90 594 849 219 2 0 1
3+5 0 0 1 6 12 2 0 0 0
4+3 0 1 29 205 322 107 2 0 0
4+4 0 0 4 32 49 23 0 0 0
4+5 0 0 6 68 113 48 4 0 0
5+3 0 0 0 5 3 4 0 0 0
5+4 0 0 2 19 25 8 2 1 0
5+5 0 0 0 3 4 2 1 0 0

 Gleason Score by Race

Gleason Score American Indian or Alaska Native Asian Black More than one race Native Hawaiian or Other Pacific Islander Unknown White
2+2 0 0 0 0 0 0 6
2+3 0 0 1 0 0 2 7
2+4 0 0 0 0 0 0 1
3+2 0 0 0 0 0 2 18
3+3 1 18 73 0 1 64 1529
3+4 1 23 136 1 0 55 1538
3+5 0 1 3 0 0 1 16
4+3 0 16 48 3 0 26 572
4+4 0 6 5 0 0 5 92
4+5 0 5 17 1 0 9 206
5+3 0 0 1 0 0 0 11
5+4 1 4 4 0 0 2 46
5+5 0 0 0 0 0 1 9

  Biochemical Recurrence by Age

Biochemical Recurrence 20-29 30-39 40-49 50-59 60-69 70-79 80-89 90-99 100-109
No 0 6 263 1446 1808 453 6 0 1
Yes 0 1 22 225 323 87 7 1 0

 Biochemical Recurrence by Race

Biochemical Recurrence American Indian or Alaska Native Asian Black More than one race Native Hawaiian or Other Pacific Islander Unknown White
No 3 75 308 7 1 153 3822
Yes 1 8 42 1 0 36 578

Metastasis by Age at Diagnosis 

Metastasis 20-29 30-39 40-49 50-59 60-69 70-79 80-89 90-99 100-109
No 0 7 281 1633 2080 515 7 0 1
Yes 0 0 4 38 51 25 6 1 0

 Metastasis by Race

Metastasis American Indian or Alaska Native Asian Black More than one race Native Hawaiian or Other Pacific Islander Unknown White
No 4 80 331 8 1 183 4219
Yes 0 3 19 0 0 6 181
Created by CDSI for the Robert H. Lurie Comprehensive Cancer Center of Northwestern University | For support issues, please email: disburser@northwestern.edu