Clinical Research Repository Disburser
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
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Repository: Prostate Spore

General

The SPORE repository has more than 50,000 specimen aliquots from more than 4,500 consented patients with prostate cancer treated at Northwestern Memorial Hospital and NorthShore University Health System. In addition to frozen tissue on nearly 3,500 patients, the repository has blood (serum, plasma, peripheral blood mononuclear cells, and blood spots) and urine samples. Sample accrual has been expanded to include not only patients undergoing surgery, but also non-surgical patients with advanced disease who are undergoing radiotherapy or chemotherapy, thus spanning the spectrum of disease. Corresponding formalin-fixed paraffin-embedded (FFPE) tissue is available on each prostatectomy case, and biopsies are available in most cases as well. More than 50 tissue microarrays have been generated and are available to interested investigators for research studies. Detailed clinical and pathologic data associated with each specimen is uploaded by data coordinators into the SPORE database sample management systems with appropriate protection of patient confidentiality.

  • IRB Process: IRB approval or exemption must be obtained prior to release of data or specimens. The request form will ask you input your IRB number or declare your your IRB exemption.
  • Scientific Justification: The request form will ask you to attach a 'Methods/Justifications' document that should contain a scientific explanation jutifying the disburment of the clincial data and/or clinical speicmens.
  • Questions:
    • For all other questions about the specimen request process, please contact:
    • To discuss your specimen needs, please contact a SPORE Biospecimen director:
Specimen

Here is a breakdown of the specimen types avaible from the Prostate SPORE:

Sampe Type Count
DNA 8
Blood MNC 4287
Blood Plasma 8460
Blood Serum 6037
Buffy+RBC 710
Core Punch 10
Fresh Tissue 62
Frozen Tissue 11442
Prostatic Fluid 1866
Seminal Vesical Fluid 634
Spun Urine 874
Stained slide, H&E 9536
Tissue FPE Block 5
Urine 1143
Whole Blood 674
Data

The  broad categories of the clinical data points collected within the Prostate SPORE are the following:

  • Demographics
  • Family History
  • Comorbidities
  • Diagnosis
  • Treatment
  • Followup
  • Survival

A complete listing of all the clinical data points available are detailed in the data dictionary document above.

Here is a high-level breakdown of the most commonly requested clinical data points available from the Prostate SPORE.

Clinical Stage by Age at Diagnosis

Clinical Stage 20-29 30-39 40-49 50-59 60-69 70-79 80-89 90-99 100-109
None 0 1 10 78 110 34 4 1 0
T1a 0 0 0 6 3 0 0 0 0
T1b 0 0 0 0 6 1 0 0 0
T1c 1 3 225 1106 1241 239 0 0 0
T2a 0 1 47 244 260 57 1 0 0
T2b 0 1 15 77 136 28 1 0 0
T2c 0 0 5 35 39 12 0 0 0
T3a 0 0 1 8 6 1 0 0 0
T3b 0 0 0 0 2 0 0 0 0
T3c 0 0 0 2 0 0 0 0 0
T4 0 0 0 0 0 0 0 0 0
Tx 0 0 0 0 1 0 0 0 0

Clinical Stage by Race

Clinical Stage American Indian or Alaska Native Asian Black More than one race Native Hawaiian or Other Pacific Islander Unknown White
None 0 3 27 0 0 51 286
T1a 0 0 1 0 0 0 10
T1b 0 0 2 0 0 0 8
T1c 3 42 195 3 1 191 2444
T2a 0 7 23 0 0 37 559
T2b 1 2 8 0 0 34 227
T2c 0 3 4 0 0 9 82
T3a 0 0 0 0 0 0 17
T3b 0 0 0 0 0 1 1
T3c 0 0 0 0 0 0 2
T4 0 0 0 0 0 0 3
Tx 0 0 0 0 0 0 1

Pathological Stage by Age at Diagnosis

Pathological Stage 20-29 30-39 40-49 50-59 60-69 70-79 80-89 90-99 100-109
None 0 0 4 17 34 16 2 1 0
N1 0 0 1 15 14 6 0 0 0
T0 0 0 0 3 2 2 0 0 0
T2a 0 2 52 227 277 49 2 0 0
T2b 0 1 16 45 38 10 0 0 0
T2c 1 1 189 936 1004 164 1 0 0
T3a 0 1 22 216 307 86 1 0 0
T3b 0 1 12 67 74 29 0 0 0
T3c 0 0 7 30 50 10 0 0 0
T4 0 0 0 0 4 0 0 0 0

Pathological Stage by Race 

Pathological Stage American Indian or Alaska Native Asian Black More than one race Native Hawaiian or Other Pacific Islander Unknown White
None 0 5 33 1 0 23 242
N1 0 1 2 0 0 2 31
T0 0 0 0 0 0 1 6
T2a 1 3 18 0 0 43 545
T2b 0 1 4 0 0 37 68
T2c 2 30 151 0 1 141 1975
T3a 0 13 30 2 0 51 541
T3b 1 3 17 0 0 19 143
T3c 0 1 4 0 0 6 86
T4 0 0 1 0 0 0 3

Gleason Score by Age at Diagnosis 

Gleason Score 20-29 30-39 40-49 50-59 60-69 70-79 80-89 90-99 100-109
None 0 0 0 1 1 0 0 0 0
2+2 0 0 0 2 2 0 0 0 0
2+3 0 0 1 3 5 0 0 0 0
2+4 0 0 0 0 1 0 0 0 0
3+2 0 0 3 4 9 2 0 0 0
3+3 1 5 162 703 650 76 2 0 0
3+4 0 0 96 549 709 154 0 0 0
3+5 0 0 1 7 9 2 0 0 0
4+3 0 1 29 170 249 67 0 0 0
4+4 0 0 5 32 47 17 0 0 0
4+5 0 0 4 57 78 32 2 0 0
5+3 0 0 0 4 2 4 0 0 0
5+4 0 0 2 13 20 5 2 1 0
5+5 0 0 0 1 3 1 0 0 0

 Gleason Score by Race

Gleason Score American Indian or Alaska Native Asian Black More than one race Native Hawaiian or Other Pacific Islander Unknown White
None 0 0 0 0 0 0 2
2+2 0 0 0 0 0 1 3
2+3 0 0 1 0 0 2 6
2+4 0 0 0 0 0 0 1
3+2 0 0 0 0 0 4 14
3+3 2 15 68 0 1 100 1414
3+4 1 14 102 0 0 124 1274
3+5 0 0 3 0 0 2 14
4+3 0 14 34 2 0 41 426
4+4 0 4 4 0 0 8 85
4+5 0 3 11 0 0 14 145
5+3 0 0 1 0 0 1 8
5+4 1 2 4 0 0 4 32
5+5 0 0 0 0 0 1 5

  Biochemical Recurrence by Age

Biochemical Recurrence 20-29 30-39 40-49 50-59 60-69 70-79 80-89 90-99 100-109
No 0 2 183 877 1015 212 3 0 0
Yes 1 4 120 679 789 160 3 1 0

 Biochemical Recurrence by Race

Biochemical Recurrence American Indian or Alaska Native Asian Black More than one race Native Hawaiian or Other Pacific Islander Unknown White
No 0 31 116 2 1 184 2045
Yes 4 26 144 1 0 139 1595

Metastasis by Age at Diagnosis 

Metastasis 20-29 30-39 40-49 50-59 60-69 70-79 80-89 90-99 100-109
No 1 6 302 1529 1770 354 4 0 0
Yes 0 0 1 27 34 18 2 1 0

 Metastasis by Race

Metastasis American Indian or Alaska Native Asian Black More than one race Native Hawaiian or Other Pacific Islander Unknown White
No 4 55 258 3 1 313 3537
Yes 0 2 2 0 0 10 103